Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTK3WBU)

• DTT Name: XIAP messenger RNA (XIAP mRNA) DTT Info
• Gene Name: XIAP

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ASTX660	DMMKW8L	Lymphoma	2A80-2A86	Phase 2	[1]
AEG35156	DM2HRYD	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EMBELIN	DMFZO4Y	N. A.	N. A.	Terminated	[3]

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARPFAQK-FAM	DMU70YP	Discovery agent	N.A.	Investigative	[3]
AVPIAQKSEK-FAM	DMNQ9R4	Discovery agent	N.A.	Investigative	[3]
AZD5582	DMPIHN6	Discovery agent	N.A.	Investigative	[4]
BV-6	DMDTV7A	Discovery agent	N.A.	Investigative	[5]
SM-122	DMC7YQE	Discovery agent	N.A.	Investigative	[6]
SM-131	DMP8VO6	Discovery agent	N.A.	Investigative	[7]
SM-337	DMOSTP9	Discovery agent	N.A.	Investigative	[6]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Teaming up to tackle RNAi delivery challenge. Nat Rev Drug Discov. 2009 Jul;8(7):525-6.
• [3] Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional... J Med Chem. 2004 May 6;47(10):2430-40.
• [4] Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919.
• [5] IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81.
• [6] Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7.
• [7] Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of ca... J Med Chem. 2008 Dec 11;51(23):7352-5.