Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTKLJYX)

DTT Name	Histone-lysine N-methyltransferase SMYD3 (SMYD3) DTT Info
Gene Name	SMYD3

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Preclinical Drug(s)

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4 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EPZ028862	DM2TESM	Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]
EPZ031686	DM8UKL0	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
EPZ0330456	DMUKVYL	Colon cancer	2B90.Z	Preclinical	[1]
GSK2807	DMAZROV	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
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Molecule Interaction Atlas

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References

1	Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
2	Therapeutical potential of deregulated lysine methyltransferase SMYD3 as a safe target for novel anticancer agents. Expert Opin Ther Targets. 2017 Feb;21(2):145-157.
3	Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781.