Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTKLW9S)

DTT Name	Hyperpolarization cyclic nucleotide-gated channel (HCN) DTT Info
Gene Name	HCN

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivabradine	DM0L594	Angina pectoris	BA40	Approved	[1]
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3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SKL-NP	DMRHD6B	Pain	MG30-MG3Z	Phase 2	[2]
ZD-7288	DMPE2B9	Angina pectoris	BA40	Phase 2	[3]
Cilobradine	DM7EAG8	Cardiac arrhythmias	BC9Z	Phase 1	[4]
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Molecule Interaction Atlas

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References

1	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
2	A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons. Korean J Physiol Pharmacol. 2012 Aug;16(4):237-41.
3	ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. World J Gastroenterol. 2014 Feb 28;20(8):2091-7.
4	Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.