Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTKPV6O)

• DTT Name: Ephrin type-B receptor 2 (EPHB2) DTT Info
• UniProt ID: EPHB2_HUMAN
• Gene Name: EPHB2

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BVD-523	DMNB4XK	Melanoma	2C30	Phase 2	[1]
SEphB4-HSA	DMD8RU0	Kaposi sarcoma	2B57	Phase 2	[2]
KO-947	DMZMSBI	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
MK-8353	DMLCTI5	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[3]
PMID19788238C66	DMCVJK9	Discovery agent	N.A.	Investigative	[4]
PMID23489211C20	DMDYC4J	Discovery agent	N.A.	Investigative	[5]
SNEWIQPRLPQH	DMYUH62	Discovery agent	N.A.	Investigative	[6]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] National Cancer Institute Drug Dictionary (drug name SEphB4-HSA).
• [3] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [4] Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46.
• [5] Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47.
• [6] Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. J Biol Chem. 2007 Dec 14;282(50):36505-13.