Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTM1EQF)

• DTT Name: Oxysterols receptor LXR (NR1H) DTT Info
• Gene Name: NR1H

Molecule-Related Drug & Molecule List

8 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALX-101	DMCAFXM	Atopic dermatitis	EA80	Phase 2	[1]
RGX-104	DM5AIKR	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[2]
BMS-779788	DMKR8S1	Arteriosclerosis	BD40	Phase 1	[3]
BMS-852927	DMZS1D2	Arteriosclerosis	BD40	Phase 1	[3]
CS-8080	DMRH740	Arteriosclerosis	BD40	Phase 1	[3]
LXR 623	DM3OP41	Arteriosclerosis	BD40	Phase 1	[3]
XL-041	DMYSQHT	Arteriosclerosis	BD40	Phase 1	[4]
XL652/XL014	DM89NML	Cardiovascular disease	BA00-BE2Z	Phase 1	[5]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
T0901317	DMZQVDI	Discovery agent	N.A.	Investigative	[6]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014 Jun;13(6):433-44.
• [4] Emerging small molecule drugs. Handb Exp Pharmacol. 2015;224:617-30.
• [5] Clinical pipeline report, company report or official report of Exelixis (2011).
• [6] The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res. 2003 Nov;44(11):2039-48.