Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTM1TDX)

DTT Name	Tryptase alpha/beta-1 (Tryptase) DTT Info
Gene Name	TPSAB1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Discontinued Drug(s)

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lactoferrin	DMA7QTC	Solid tumour/cancer	2A00-2F9Z	Approved	[1]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[1]
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5 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
APC-2059	DM8IB6K	Inflammatory bowel disease	DD72	Discontinued in Phase 2	[2]
APC-366	DM02DNQ	Asthma	CA23	Discontinued in Phase 2	[1]
BABIM	DM8AGOE	Asthma	CA23	Terminated	[1]
BAY-17-1998	DM7LZFQ	Asthma	CA23	Terminated	[3]
BAY-44-3428	DM40ORU	Asthma	CA23	Terminated	[4]
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4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMG-126737	DM9H7AZ	Discovery agent	N.A.	Investigative	[5]
BMS-262084	DMETNA3	Discovery agent	N.A.	Investigative	[6]
Grassystatin a	DM1PWX2	Discovery agent	N.A.	Investigative	[7]
MOL 6131	DMSF8UC	Discovery agent	N.A.	Investigative	[5]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96.
2	Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002 Mar;16(3):407-13.
3	Bayer AG to Develop Arris Asthma Compound; Arris to Receive Milestone Payment. 1996 Business Wire
4	Bayer AG to Develop Arris Asthma Compound; Arris to Receive Milestone Payment. 1996 Business Wire
5	Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol. 2002 Feb 15;168(4):1992-2000.
6	Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3229-33.
7	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.