Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTMHA6L)

• DTT Name: T-cell surface glycoprotein CD8 (CD8) DTT Info
• UniProt ID: CD8A_HUMAN; CD8B_HUMAN
• Gene Name: CD8A; CD8B

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoropeptide vaccine	DMCEUOH	Influenza virus infection	1E30-1E32	Phase 2	[1]
Anti-VEGFR2 CD8 cell therapy	DM2910G	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2], [3]
LIPO-4	DMJRALD	Human immunodeficiency virus infection	1C62	Phase 1	[4]

References

• [1] A novel peptide-based pan-influenza A vaccine: a double blind, randomised clinical trial of immunogenicity and safety. Vaccine. 2015 Jan 3;33(2):396-402.
• [2] Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17561-6.
• [3] ClinicalTrials.gov (NCT01218867) CAR T Cell Receptor Immunotherapy Targeting VEGFR2 for Patients With Metastatic Cancer. U.S. National Institutes of Health.
• [4] Long-term CD4(+) and CD8(+) T-cell responses induced in HIV-uninfected volunteers following intradermal or intramuscular administration of an HIV-lipopeptide vaccine (ANRS VAC16). Vaccine. 2013 Sep 13;31(40):4406-15.