Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTMS7KP)

DTT Name	Protein-tyrosine phosphatase 1B (PTP1B) DTT Info
Gene Name	PTPN1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IONIS-PTP1BRX	DMGTJUP	Type-2 diabetes	5A11	Phase 2	[1]
TTP-814	DMH9RGV	Diabetic complication	5A2Y	Phase 1/2	[2]
KQ-791	DMK0BTN	Type-2 diabetes	5A11	Phase 1	[1]
Trodusquemine	DMQ7UN6	Breast cancer	2C60-2C65	Phase 1	[3]
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1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JTT-551	DM48HVI	Type-2 diabetes	5A11	Terminated	[4]
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Molecule Interaction Atlas

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Protein tyrosine phosphatase 1B (PTP-1B; PTPN1). SciBX 5(7); doi:10.1038/scibx.2012.176. Feb. 16 2012
3	Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-23.
4	Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice. J Diabetes Res. 2014;2014:680348.