Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTMSB0A)

• DTT Name: Integrin alpha-2/beta-1 (ITGA2/B1) DTT Info
• Gene Name: ITGA2-ITGB1

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SAR-339658	DMJ9RN8	Inflammatory bowel disease	DD72	Phase 2	[1]
Valetizumab	DMIKH67	Multiple sclerosis	8A40	Phase 2	[2]
Vatelizumab	DM3V7QO	Multiple sclerosis	8A40	Phase 2	[2]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Evatak	DMNMEAW	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
TCI15	DM06DI1	Discovery agent	N.A.	Investigative	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2578).
• [2] Sulfonamide inhibitors of alpha2beta1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation. Pharmacol Res Perspect. 2015 June; 3(3): e00146.
• [3] Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24.