Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTMUG9D)

• DTT Name: MAPK-activated protein kinase 2 (MAPKAPK2) DTT Info
• UniProt ID: MAPK2_HUMAN
• Gene Name: MAPKAPK2

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CBP-501	DMCWVPU	Mesothelioma	2C51.2	Phase 1/2	[1]
MMI-0100	DMIMVEX	Airway inflammation	CA05	Phase 1	[2]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CMPD1	DMKNUYF	Discovery agent	N.A.	Investigative	[3]
PF-3644022	DM6KVIA	Discovery agent	N.A.	Investigative	[4]
PMID17480064C16	DM4IABG	Discovery agent	N.A.	Investigative	[5]
PMID19364658C33	DMSE1C3	Discovery agent	N.A.	Investigative	[6]

References

• [1] National Cancer Institute Drug Dictionary (drug id 577812).
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2094).
• [3] Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6832-5.
• [4] A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther. 2010 Jun;333(3):797-807.
• [5] Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54.
• [6] Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51.