Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTNAHEX)

• DTT Name: cAMP-dependent protein kinase A type I (PRKAR1A) DTT Info
• Gene Name: PRKAR1A

Molecule-Related Drug & Molecule List

18 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline	DMV3KBE	Discovery agent	N.A.	Investigative	[1]
AdcAhxArg4Lys(biotin)-PEG-OMe	DMZYJHV	Discovery agent	N.A.	Investigative	[2]
AdcAhxArg4Lys-PEGOMe	DMQ2C8X	Discovery agent	N.A.	Investigative	[2]
AdcAhxArg4NH(CH2)6NH2	DMSYMRJ	Discovery agent	N.A.	Investigative	[2]
AdcAhxArg6	DM7J3K0	Discovery agent	N.A.	Investigative	[2]
AdoC(Ahx)Arg6	DMW5HO0	Discovery agent	N.A.	Investigative	[3]
AdoC(Aoc)Arg6	DMRSCO2	Discovery agent	N.A.	Investigative	[3]
AdoC(Aun)Arg6	DMDLHAB	Discovery agent	N.A.	Investigative	[3]
AdoC(beta-Ala)2AlaArg6	DMPUAFC	Discovery agent	N.A.	Investigative	[3]
AdoC(beta-Ala)Arg6	DMO8D4V	Discovery agent	N.A.	Investigative	[3]
AdoC(betaAsp)2AlaArg6	DM65B7Y	Discovery agent	N.A.	Investigative	[3]
AdoC(Dpr)2AlaArg6	DM2TWSZ	Discovery agent	N.A.	Investigative	[3]
AdoC(GABA)Arg6	DMMWNPT	Discovery agent	N.A.	Investigative	[3]
AdoCGlyArg6	DMVQJP0	Discovery agent	N.A.	Investigative	[3]
Cyclic Guanosine Monophosphate	DMOU93V	Discovery agent	N.A.	Investigative	[4]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[5]
Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate	DM1VQ4K	Discovery agent	N.A.	Investigative	[4]
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[4]

References

• [1] Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and... J Biol Chem. 1996 Oct 18;271(42):26157-64.
• [2] Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.
• [3] Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.