Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTNAY0P)

• DTT Name: Monocyte chemotactic and activating factor (CCL2) DTT Info
• Gene Name: CCL2

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bindarit	DMS2GA1	Nephritis	GB40	Phase 3	[1]
Carlumab	DMAUN15	Pulmonary fibrosis	CB03.4	Phase 2	[2]
NOX-E36	DMHG3UR	Diabetic complication	5A2Y	Phase 2	[3]
CNTO888	DMUBP0V	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABN-912	DMADKHB	Asthma	CA23	Discontinued in Phase 1	[5]

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MCP-1	DMYEFKH	Rheumatoid arthritis	FA20	Preclinical	[6]
RS-504393	DMB9IPR	Chronic obstructive pulmonary disease	CA22	Preclinical	[7]

References

• [1] Bindarit: an anti-inflammatory small molecule that modulates the NF B pathway. Cell Cycle. 2012 Jan 1;11(1):159-69.
• [2] Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study. Target Oncol. 2015 Mar;10(1):111-23.
• [3] Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2. Nat Commun. 2015 Apr 22;6:6923.
• [4] CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration. Neoplasia. 2007 Jul;9(7):556-62.
• [5] A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis. Arthritis Rheum. 2006 Aug;54(8):2387-92.
• [6] Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
• [7] Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19.