Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTNIZ2B)

DTT Name	PCSK9 messenger RNA (PCSK9 mRNA) DTT Info
Gene Name	PCSK9

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Download the Complete Related Drug List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Inclisiran	DMP3YTE	Familial hypercholesterolemia	5C80.00	Approved	[1]
------------------------------------------------------------------------------------

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD8233	DMBT2D2	Cardiovascular disease	BA00-BE2Z	Phase 2	[2]
MPSK3169A	DMMRYEK	Cardiovascular disease	BA00-BE2Z	Phase 2	[3]
------------------------------------------------------------------------------------

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALN-PCS	DMCJMOS	Hypercholesterolaemia	5C80.0	Preclinical	[4]
BMS-PCSK9	DMRCMEK	Coronary artery disease	BA80	Preclinical	[5]
------------------------------------------------------------------------------------

Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	FDA Approved Drug Products from FDA Official Website. 2021. Application Number: 214012.
2	AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval. Br J Clin Pharmacol. 2022 Nov;88(11):4839-4844.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2388).
4	Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011).
5	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).