Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTNVC34)

DTT Name	Short transient receptor potential channel 3 (TRPC3) DTT Info
UniProt ID	TRPC3_HUMAN
Gene Name	TRPC3

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Investigative Drug(s)

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6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[1]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[2]
BTP2	DMNM63G	Discovery agent	N.A.	Investigative	[3]
KB-R7943	DMMD5W3	Discovery agent	N.A.	Investigative	[2]
OAG	DMOP8IJ	Discovery agent	N.A.	Investigative	[4]
Pyr3	DM3VNYQ	Discovery agent	N.A.	Investigative	[5]
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Molecule Interaction Atlas

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References

1	Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. Mol Pharmacol. 2005 Sep;68(3):758-62.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488).
3	A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J Biol Chem. 2005 Mar 25;280(12):10997-1006.
4	Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63.
5	Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5.