Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTO0IB8)

• DTT Name: Thymidine phosphorylase (TYMP) DTT Info
• UniProt ID: TYPH_HUMAN
• Gene Name: TYMP

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Uridine	DMQTREB	Depression	6A70-6A7Z	Approved	[1]

23 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-(cyclohexyl)methyl-5'-O-tritylinosine	DMS3XUC	Discovery agent	N.A.	Investigative	[2]
1-(cyclopropyl)methyl-5'-O-tritylinosine	DMDU3X7	Discovery agent	N.A.	Investigative	[2]
1-allyl-5'-O-tritylinosine	DM2J5WH	Discovery agent	N.A.	Investigative	[2]
1-benzyl-5'-O-tritylinosine	DMH0ZVR	Discovery agent	N.A.	Investigative	[2]
1-propyl-5'-O-tritylinosine	DM5P01L	Discovery agent	N.A.	Investigative	[2]
2'-aminoimidazolylmethyluracils	DMUJC2E	Discovery agent	N.A.	Investigative	[3]
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione	DMCKODQ	Discovery agent	N.A.	Investigative	[4]
5-bromo-6-(cyclopropylamino)uracil hydrochloride	DMRY0OL	Discovery agent	N.A.	Investigative	[5]
5-bromo-6-hydrazinouracil hydrochloride	DMZJE6M	Discovery agent	N.A.	Investigative	[5]
5-butyl-6-chloropyrimidine-2,4(1H,3H)-dione	DMFKMYV	Discovery agent	N.A.	Investigative	[4]
5-chloro-6-hydrazinouracil hydrochloride	DMMT7WO	Discovery agent	N.A.	Investigative	[5]
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil	DMEV0GO	Discovery agent	N.A.	Investigative	[6]
6-amino-5-bromouracil	DM5SZHR	Discovery agent	N.A.	Investigative	[7]
6-amino-5-chlorouracil hydrochloride	DMFPCSJ	Discovery agent	N.A.	Investigative	[5]
6-bromo-5-phenylpyrimidine-2,4(1H,3H)-dione	DM8A1ZU	Discovery agent	N.A.	Investigative	[4]
6-chloro-5-(2-thienyl)pyrimidine-2,4(1H,3H)-dione	DMSZML2	Discovery agent	N.A.	Investigative	[4]
6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione	DMASFR6	Discovery agent	N.A.	Investigative	[4]
6-chloro-5-hexylpyrimidine-2,4(1H,3H)-dione	DMP4V8Y	Discovery agent	N.A.	Investigative	[4]
6-chloro-5-pentylpyrimidine-2,4(1H,3H)-dione	DMUJSP7	Discovery agent	N.A.	Investigative	[4]
6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione	DM90JMN	Discovery agent	N.A.	Investigative	[4]
6-chloro-5-propylpyrimidine-2,4(1H,3H)-dione	DMB24LJ	Discovery agent	N.A.	Investigative	[4]
6-fluoro-5-phenylpyrimidine-2,4(1H,3H)-dione	DM4Q5TX	Discovery agent	N.A.	Investigative	[4]
Thymine	DMKGXB9	Discovery agent	N.A.	Investigative	[8]

References

• [1] Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10.
• [2] 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70.
• [3] Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase. J Med Chem. 2003 Jan 16;46(2):207-9.
• [4] Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23.
• [5] Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7.
• [6] The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51.
• [7] Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors. Eur J Med Chem. 2008 Jun;43(6):1248-60.
• [8] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.