General Information of DTT (ID: TTOFXD7)

DTT Name Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) DTT Info
Gene Name EHMT1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Preclinical Drug(s)
Investigative Drug(s)
2 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
A-366 DM1H45U Solid tumour/cancer 2A00-2F9Z Preclinical [1]
BIX-01294 DM5CBNY Breast cancer 2C60-2C65 Preclinical [2]
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2 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
UNC0638 DM4A1KJ Discovery agent N.A. Investigative [3]
UNC0642 DM7Y1SO Discovery agent N.A. Investigative [4]
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Molecule Interaction Atlas

References

1 Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS Med Chem Lett. 2014 Jan 2;5(2):205-9.
2 Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007 Feb 9;25(3):473-81.
3 A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74.
4 Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-42.