General Information of DTT (ID: TTOJ1NF)

DTT Name FMLP-related receptor I (FPR2) DTT Info
Gene Name FPR2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Preclinical Drug(s)
Investigative Drug(s)
1 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
humanin DMUAPNF Alzheimer disease 8A20 Preclinical [1]
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13 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
AG-26 DMMFQR2 Discovery agent N.A. Investigative [2]
aspirin triggered lipoxin A4 DMLBSNP Discovery agent N.A. Investigative [3]
aspirin-triggered resolvin D1 DMOP941 Discovery agent N.A. Investigative [4]
ATLa2 DMA632U Discovery agent N.A. Investigative [5]
fMet-Leu-Phe DMQ391A N. A. N. A. Investigative [6]
LXA4 DMGSVL0 Discovery agent N.A. Investigative [7]
PMID22607879CR-(-)-5f DM7OJ5Q Discovery agent N.A. Investigative [8]
PMID23788657C1754-31 DM2FDJN Discovery agent N.A. Investigative [9]
pyrazolone, 1 DMLFQKU Discovery agent N.A. Investigative [10]
quin-C1 DMVQYWS Discovery agent N.A. Investigative [11]
quin-C7 DM1CYWB Discovery agent N.A. Investigative [12]
RvD1-ME DM8EZTM Discovery agent N.A. Investigative [4]
[3H]resolvin D1 DMFT0HU Discovery agent N.A. Investigative [7]
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⏷ Show the Full List of 13 Investigative Drug(s)
Molecule Interaction Atlas

References

1 N-Formylated humanin activates both formyl peptide receptor-like 1 and 2. Biochem Biophys Res Commun. 2004 Nov 5;324(1):255-61.
2 Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition. Mol Pharmacol. 2010 Feb;77(2):159-70.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 223).
4 Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May;180(5):2018-27.
5 Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo. J Med Chem. 2004 Apr 8;47(8):2157-65.
6 Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors. J Biol Chem. 1993 Aug 25;268(24):18167-75.
7 Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5.
8 Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists. Bioorg Med Chem. 2012 Jun 15;20(12):3781-92.
9 Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries. Mol Pharmacol. 2013 Sep;84(3):314-24.
10 Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8.
11 A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol Pharmacol. 2004 Nov;66(5):1213-22.
12 Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol Pharmacol. 2007 Oct;72(4):976-83.