Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTONI0R)

• DTT Name: PKC-eta messenger RNA (PRKCH mRNA) DTT Info
• Gene Name: PRKCH

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[1]

13 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
8-Octyl-benzolactam-V9	DM4Z15M	Discovery agent	N.A.	Investigative	[2]
ISIS 6431	DMEUCI2	Discovery agent	N.A.	Investigative	[3]
ISIS 6432	DMQHN43	Discovery agent	N.A.	Investigative	[3]
ISIS 6434	DMNVLE2	Discovery agent	N.A.	Investigative	[3]
ISIS 6435	DMI7JQG	Discovery agent	N.A.	Investigative	[3]
ISIS 6442	DM7KSRG	Discovery agent	N.A.	Investigative	[3]
ISIS 6443	DMGN051	Discovery agent	N.A.	Investigative	[3]
ISIS 6445	DMXJ4SO	Discovery agent	N.A.	Investigative	[3]
ISIS 6553	DM5L387	Discovery agent	N.A.	Investigative	[3]
ISIS 6581	DMEAVPQ	Discovery agent	N.A.	Investigative	[3]
ISIS 6603	DMVXC7W	Discovery agent	N.A.	Investigative	[3]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[4]
PROSTRATIN	DM1HMJ5	Human immunodeficiency virus infection	1C62	Investigative	[5]

References

• [1] Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995).
• [2] Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8.
• [3] US patent application no. 5,959,096, Antisense oligonucleotides against human protein kinase C.
• [4] (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71.
• [5] A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86.