Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTOQCD8)

• DTT Name: Apoptosis signal-regulating kinase 1 (MAP3K5) DTT Info
• Gene Name: MAP3K5

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GS-4977	DMBDFN7	Diabetic nephropathy	GB61.Z	Phase 2	[1]
GS-4997	DMNABMU	Diabetic nephropathy	GB61.Z	Phase 2	[1]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MSC2032964A	DMS3O9H	Discovery agent	N.A.	Investigative	[2]
PMID23147077C10	DM3Z6F4	Discovery agent	N.A.	Investigative	[3]

References

• [1] Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33.
• [2] Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med. 2010 Dec;2(12):504-15.
• [3] Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9.