Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTPHMWB)

• DTT Name: Aminopeptidase N (ANPEP) DTT Info
• Gene Name: ANPEP

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IP10 C8	DMANRGW	Psoriasis vulgaris	EA90	Phase 2	[1]

39 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(1-Amino-2-phenyl-ethyl)-phosphinic acid	DMXD8H1	Discovery agent	N.A.	Investigative	[2]
(1-Amino-3-methyl-butyl)-phosphinic acid	DMNUO79	Discovery agent	N.A.	Investigative	[2]
(1-Amino-3-methylsulfanyl-propyl)-phosphinic acid	DMJL8QZ	Discovery agent	N.A.	Investigative	[2]
(1-Amino-3-phenyl-propyl)-phosphinic acid	DMXD697	Discovery agent	N.A.	Investigative	[2]
(1-Amino-ethyl)-phosphinic acid	DMUACZF	Discovery agent	N.A.	Investigative	[2]
(Amino-phenyl-methyl)-phosphinic acid	DMS4ZVK	Discovery agent	N.A.	Investigative	[2]
(S)-2-Amino-2-phenyl-ethanethiol	DMFEGPX	Discovery agent	N.A.	Investigative	[2]
(S)-2-Amino-3-phenyl-propane-1-thiol	DMMAUKO	Discovery agent	N.A.	Investigative	[2]
(S)-2-Amino-4-methyl-pentane-1-thiol	DM96XYI	Discovery agent	N.A.	Investigative	[2]
(S)-2-Amino-4-methylsulfanyl-butane-1-thiol	DMOVQ1T	Discovery agent	N.A.	Investigative	[2]
(S)-2-Amino-4-phenyl-butane-1-thiol	DMJEGMI	Discovery agent	N.A.	Investigative	[2]
(S)-2-Amino-propane-1-thiol	DMYG8EV	Discovery agent	N.A.	Investigative	[2]
1-aminobutylphosphonic acid	DM4TFN6	Discovery agent	N.A.	Investigative	[3]
1-aminohexylphosphonic acid	DMFUABI	Discovery agent	N.A.	Investigative	[3]
1-aminohexylphosphonic acid monophenyl ester	DML6UJM	Discovery agent	N.A.	Investigative	[3]
1-aminopentylphosphonic acid monophenyl ester	DMMV30B	Discovery agent	N.A.	Investigative	[3]
2-amino-N1-benzyl-N3-hydroxymalonamide	DMQ30UY	Discovery agent	N.A.	Investigative	[4]
2-benzyl-N1-hydroxy-N3-(3-phenylpropyl)malonamide	DMF5MGQ	Discovery agent	N.A.	Investigative	[4]
2-benzyl-N1-hydroxy-N3-(4-phenylbutyl)malonamide	DMRVA94	Discovery agent	N.A.	Investigative	[4]
2-benzyl-N1-hydroxy-N3-phenethylmalonamide	DM2BPIN	Discovery agent	N.A.	Investigative	[4]
2-Cinnamamido-N1-hydroxy-N4-octylsuccinamide	DMXYTGU	Discovery agent	N.A.	Investigative	[5]
2-Cinnamamido-N1-hydroxy-N4-pentylsuccinamide	DMI6FZN	Discovery agent	N.A.	Investigative	[5]
2-Cinnamamido-N4-hexyl-N1-hydroxysuccinamide	DMRNGK7	Discovery agent	N.A.	Investigative	[5]
Angiotensin IV	DMR9OD1	Discovery agent	N.A.	Investigative	[6]
KELATORPHAN	DMOX8FD	Discovery agent	N.A.	Investigative	[7]
N-biphenyl-3-ylmethyl-N'-hydroxy-malonamide	DMJF9VA	Discovery agent	N.A.	Investigative	[4]
N-Hydroxy-2-(naphthalen-2-ylsulfanyl)-acetamide	DMISXUM	Discovery agent	N.A.	Investigative	[8]
N1,2-dibenzyl-N3-hydroxy-N1-phenethylmalonamide	DM1L89K	Discovery agent	N.A.	Investigative	[4]
N1,2-dibenzyl-N3-hydroxymalonamide	DMM59IS	Discovery agent	N.A.	Investigative	[4]
N1-(3,3-diphenylpropyl)-N3-hydroxymalonamide	DM5F04D	Discovery agent	N.A.	Investigative	[4]
N1-(3-phenoxybenzyl)-N3-hydroxymalonamide	DMSRHJA	Discovery agent	N.A.	Investigative	[4]
N1-(4-chlorobenzyl)-2-amino-N3-hydroxymalonamide	DMJ025O	Discovery agent	N.A.	Investigative	[4]
N1-(4-chlorobenzyl)-2-benzyl-N3-hydroxymalonamide	DMTMDZ4	Discovery agent	N.A.	Investigative	[4]
N1-(4-fluorobenzyl)-2-benzyl-N3-hydroxymalonamide	DMS1P85	Discovery agent	N.A.	Investigative	[4]
N1-benzyl-N3-hydroxy-2-isobutylmalonamide	DMXSFWK	Discovery agent	N.A.	Investigative	[9]
N1-hydroxy-2-isobutyl-N3-phenethylmalonamide	DMF6RVS	Discovery agent	N.A.	Investigative	[9]
N4-Butyl-2-cinnamamido-N1-hydroxysuccinamide	DM1N73J	Discovery agent	N.A.	Investigative	[5]
PMID23428964CI3	DMZUQ7X	Discovery agent	N.A.	Investigative	[10]
[(125)I] RB129	DMX0G7E	Discovery agent	N.A.	Investigative	[11]

References

• [1] Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin Chem Lab Med. 2009;47(3):253-61.
• [2] Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6.
• [3] New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2010 Apr 15;18(8):2930-6.
• [4] Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34.
• [5] Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2009 Oct 15;17(20):7398-404.
• [6] Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2. Bioorg Med Chem. 2008 Jul 15;16(14):6924-35.
• [7] Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem. 1988 Sep;31(9):1825-31.
• [8] N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity. Bioorg Med Chem Lett. 2005 Jan 3;15(1):181-3.
• [9] A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening. Bioorg Med Chem. 2007 Jan 1;15(1):63-76.
• [10] Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy. Bioorg Med Chem. 2013 Apr 1;21(7):2135-44.
• [11] Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography. Biochimie. 2004 Feb;86(2):105-13.