Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTPM6HI)

• DTT Name: Interleukin-1 alpha (IL1A) DTT Info
• Gene Name: IL1A

Molecule-Related Drug & Molecule List

5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MABp1	DM8D13S	Colorectal cancer	2B91.Z	Phase 3	[1]
Xilonix	DMK34MZ	Colorectal cancer	2B91.Z	Phase 3	[2]
ABT-981	DM6PTIX	Osteoarthritis	FA00-FA05	Phase 2	[3]
Bermekimab	DM7A592	Hidradenitis suppurativa	ED92.0	Phase 2	[4]
Natrunix	DMBRSWJ	Arthritis	FA20	Phase 2	[5]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IX207-887	DM4TE8R	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[6]
IL1aQb	DMKS4Z9	Arteriosclerosis	BD40	Terminated	[7]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Interleukin-1-alpha - Amgen/Roche	DMB9AIX	Discovery agent	N.A.	Investigative	[8]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of xbiotech.
• [3] Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1alpha and IL-1beta. MAbs. 2015;7(3):605-19.
• [4] Target molecules for future hidradenitis suppurativa treatment. Exp Dermatol. 2021 Jun;30 Suppl 1:8-17.
• [5] ClinicalTrials.gov (NCT05363917) Phase II Double-Blinded, Placebo-Controlled Randomized Study Examining the Safety and Efficacy of Natrunix Versus Methotrexate (+Folate) for the Treatment of Rheumatoid Arthritis. U.S.National Institutes of Health.
• [6] Inhibition of interleukin-1 release by IX 207-887. Agents Actions. 1990 Jun;30(3-4):350-62.
• [7] Cytos Biotechnology AG - Product Pipeline Review - 2013. Global Markets Direct. Dec 2013.
• [8] Identification of regions in interleukin-1 alpha important for activity. J Biol Chem. 1993 Oct 15;268(29):22105-11.