Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTPOYU7)

• DTT Name: Transthyretin messenger RNA (TTR mRNA) DTT Info
• Gene Name: TTR

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplontersen	DMON9CY	Amyloid polyneuropathy	5D00.20	Approved	[1]
Patisiran	DMWSA0V	Amyloidosis	5D00	Approved	[2]
Vutrisiran	DMM1Z9G	Hereditary amyloidosis	5D00.2	Approved	[3]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS-TTR	DM4U5NF	Amyloidosis	5D00	Phase 3	[4]
Revusiran	DM5E73H	Amyloidosis	5D00	Phase 3	[2]
ALN-TTR01	DMCSEUY	Amyloidosis	5D00	Phase 1	[5]

References

• [1] FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 217388
• [2] Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc.
• [3] Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals.
• [4] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
• [5] Safety and efficacy of RNAi therapy for transthyretin amyloidosis. N Engl J Med. 2013 Aug 29;369(9):819-29.