Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTPRO7W)

• DTT Name: Suppressor of tumorigenicity 14 protein (ST14) DTT Info
• Gene Name: ST14

Molecule-Related Drug & Molecule List

4 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US8569313, Inhibitor 14	DMZV6YT	N. A.	N. A.	Patented	[1]
US8569313, Inhibitor 15	DMTMG02	N. A.	N. A.	Patented	[1]
US8569313, Inhibitor 18	DMXTCGM	N. A.	N. A.	Patented	[1]
US8569313, Inhibitor 19	DMLXG43	N. A.	N. A.	Patented	[1]

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-nas-phe(3-am)-4-(2-guanidinoethyl)piperidine	DMFXKN1	Discovery agent	N.A.	Investigative	[2]
3-tapap	DMKSUV9	Discovery agent	N.A.	Investigative	[2]
Benzamidine	DM37GWL	Discovery agent	N.A.	Investigative	[3]
Inhibitor 1 [Colombo et al., 2012]	DMUQHMP	Discovery agent	N.A.	Investigative	[4]
PMID23849879C3	DMUW3MT	Discovery agent	N.A.	Investigative	[5]
PMID25489658C4d	DMWZJT0	Discovery agent	N.A.	Investigative	[6]

References

• [1] Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors. US8569313.
• [2] Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem. 2006 Jul 13;49(14):4116-26.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2418).
• [5] 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4547-51.
• [6] Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem. 2015 Jan 22;58(2):598-612.