Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTQ7R2V)

• DTT Name: Tripeptidyl-peptidase II (TPP2) DTT Info
• Gene Name: TPP2

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
UCL-2000; butabindide	DML51D0	Obesity	5B81	Discontinued in Phase 1	[1]

18 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(2S)-aminobutyryl-(R)-pipecolinic acid amide	DMWQK86	Discovery agent	N.A.	Investigative	[2]
(2S)-aminobutyryl-L-prolinamide	DMG0QKL	Discovery agent	N.A.	Investigative	[2]
(2S)-aminobutyryl-L-proline (R)-sec-butylamide	DMTFP0Z	Discovery agent	N.A.	Investigative	[2]
(2S)-aminobutyryl-L-proline isobutylamide	DMO5ZEK	Discovery agent	N.A.	Investigative	[2]
(2S)-aminobutyryl-L-proline n-butylamide	DM12Q9O	Discovery agent	N.A.	Investigative	[2]
(2S)-aminobutyryl-L-proline n-pentylamide	DM1DJX2	Discovery agent	N.A.	Investigative	[2]
(2S)-aminobutyryl-L-proline n-propylamide	DM6WXJO	Discovery agent	N.A.	Investigative	[2]
(2S)-aminobutyryl-L-proline-(2S)-methylbutylamide	DMEWU6Z	Discovery agent	N.A.	Investigative	[2]
Alpha-methylalanyl-L-proline butylamide	DM7DBTZ	Discovery agent	N.A.	Investigative	[2]
example 8 [WO1999033801A1]	DMFSHXW	Discovery agent	N.A.	Investigative	[3]
L-isoleucyl-L-prolinamide	DMVSAUL	Discovery agent	N.A.	Investigative	[2]
L-leucyl-L-prolinamide	DM41MS3	Discovery agent	N.A.	Investigative	[2]
L-norleucyl-L-prolinamide	DM7V30L	Discovery agent	N.A.	Investigative	[2]
L-norvalyl-L-prolinamide	DMIXFGC	Discovery agent	N.A.	Investigative	[2]
L-valyl-L-prolinamide	DMH7TNA	Discovery agent	N.A.	Investigative	[2]
L-valyl-L-proline benzylamide	DMQZ13A	Discovery agent	N.A.	Investigative	[2]
L-valyl-L-proline hexylamide	DMX4DRV	Discovery agent	N.A.	Investigative	[2]
peptide 4	DM45RTZ	Discovery agent	N.A.	Investigative	[4]

References

• [1] Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
• [2] Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2423).
• [4] Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett. 2008 May 15;18(10):3025-8.