Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTQFBMY)

• DTT Name: IGF1R messenger RNA (IGF1R mRNA) DTT Info
• UniProt ID: IGF1R_HUMAN
• Gene Name: IGF1R

Molecule-Related Drug & Molecule List

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ATL-1101	DM4XZU2	Psoriatic disorder	EA90	Preclinical	[1]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AG 1024	DMF0SPB	Discovery agent	N.A.	Investigative	[2]
AZD3463	DMAX9C3	Discovery agent	N.A.	Investigative	[3]
GSK-1838705A	DM4HLK3	Discovery agent	N.A.	Investigative	[4]
GSK1511931	DMZUTXW	Discovery agent	N.A.	Investigative	[5]
PQ401	DMVNHTE	Discovery agent	N.A.	Investigative	[6]

References

• [1] Clinical pipeline report, company report or official report of Antisense Therapeutics.
• [2] Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr;138(4):1427-33.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1801).
• [4] Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51.
• [5] Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R: elimination of an acid-mediated decomposition pathway. Bioorg Med Chem Lett. 2009 Jan 15;19(2):373-7.
• [6] Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther. 2006 Apr;5(4):1079-86.