Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTR7B60)

• DTT Name: X-linked inhibitor of apoptosis protein (XIAP) DTT Info
• Gene Name: XIAP

Molecule-Related Drug & Molecule List

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-406	DMVJW0S	Squamous head and neck cell carcinom	2D60.0	Phase 3	[1]
Birinapant	DM6PBUM	Lymphoma	2A80-2A86	Phase 2	[2]
Phenoxodiol	DMBUJVX	Ovarian cancer	2C73	Phase 1/2	[3]
APG-1387	DMLEKUY	Haematological malignancy	2B33.Y	Phase 1	[4]
GDC-0152	DM1B3UM	Obesity	5B81	Phase 1	[5]
HGS-1029	DMS9WXG	Haematological malignancy	2B33.Y	Phase 1	[6]

34 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25980951-Compound-1	DMYPT2H	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-10	DME3ZJO	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-11	DMZ9LSY	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-12	DMG8K1P	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-13	DMGHR4D	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-14	DM637IC	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-15	DMB2MIT	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-19	DMGIV0M	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-20	DMM45AC	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-21	DMIE0MR	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-22	DM6OEHK	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-26	DMK9DH7	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-27	DMXAH9F	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-28	DMV0EIA	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-29	DM5WIX3	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-3	DMPSWXU	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-30	DMXCSHE	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-31	DMC1Y2T	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-32	DMXETA8	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-33	DMYO9UD	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-36	DMBD4K9	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-37	DMHP6J2	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-38	DMEUBDA	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-39	DMEZ3QV	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-4	DM9RZSH	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-40	DMJOD8I	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-41	DMNROIP	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-42	DM8XESD	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-43	DMTJRCS	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-44	DMS5896	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-45	DM1EU06	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-5	DMB3IZT	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-6	DMVSW5N	N. A.	N. A.	Patented	[7]
PMID25980951-Compound-7	DMF8V5J	N. A.	N. A.	Patented	[7]

References

• [1] Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung c... Am J Cancer Res. 2014 Nov 19;4(6):943-51.
• [2] cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 2014 Apr 17;123(16):2562-72.
• [3] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [4] XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells.Theranostics. 2018 Feb 5;8(6):1494-1510.
• [5] Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem. 2012 May 10;55(9):4101-13.
• [6] Clinical pipeline report, company report or official report of Aegera Therapeutics Inc.
• [7] Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74.