Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTSDVTR)

• DTT Name: G-protein coupled bile acid receptor 1 (GPBAR1) DTT Info
• UniProt ID: GPBAR_HUMAN
• Gene Name: GPBAR1

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium taurocholate	DM3GO0J	Type-2 diabetes	5A11	Phase 1/2	[1]

2 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID29649907-Compound-8	DMV2D5M	N. A.	N. A.	Patented	[2]
PMID29649907-Compound-INT767	DMA0RI8	N. A.	N. A.	Patented	[2]

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
INT-767	DMRJ9P4	Hepatic fibrosis	DB93.0	Preclinical	[3]
XL475	DMD8TNK	Type-2 diabetes	5A11	Preclinical	[4]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bile acid	DMIY2HW	Discovery agent	N.A.	Investigative	[5]
INT-777	DMTPB8A	Metabolic disorder	5C50-5D2Z	Investigative	[6]

References

• [1] Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.Acta Pharmaceutica Sinica B Volume 5, Issue 2, March 2015, Pages 151-157.
• [2] Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364.
• [3] FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol. 2018 Jan;29(1):118-137.
• [4] Clinical pipeline report, company report or official report of Exelixis (2011).
• [5] Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5718-21.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 37).