Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTSLI08)

• DTT Name: Adenosine receptor (ADOR) DTT Info
• Gene Name: ADOR

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[1]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DIADENOSINE TETRAPHOSPHATE	DMTJOEL	Cardiac arrhythmias	BC9Z	Phase 2	[2]
NIR178	DMPER4A	Non-hodgkin lymphoma	2B33.5	Phase 2	[3]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
M-216765	DMUIGM3	Hypertension	BA00-BA04	Terminated	[4]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
8-sulfophenyl theophylline	DMOHB3Z	Discovery agent	N.A.	Investigative	[5]
GNF-PF-2224	DM26UKN	Discovery agent	N.A.	Investigative	[5]
SPT	DM94RJW	Discovery agent	N.A.	Investigative	[6]

References

• [1] Emerging adenosine receptor agonists. Expert Opin Emerg Drugs. 2007 Sep;12(3):479-92.
• [2] Negative chronotropic and inotropic effects exerted by diadenosine hexaphosphate (AP6A) via A1-adenosine receptors. Br J Pharmacol. 1996 Nov;119(5):835-44.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] US patent application no. 2010,0009,934, Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders.
• [5] Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001 Dec;117(6):1594-600.
• [6] Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts. J Mol Cell Cardiol. 1995 Mar;27(3):883-92.