Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTSN6QU)

• DTT Name: HIF1-alpha messenger RNA (HIF1A mRNA) DTT Info
• UniProt ID: HIF1A_HUMAN
• Gene Name: HIF1A

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PT2385	DMCSN69	Recurrent glioblastoma	2A00.00	Phase 2	[1]

13 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol	DM15P2G	Discovery agent	N.A.	Investigative	[2]
ISIS 175510	DMPAXR4	Discovery agent	N.A.	Investigative	[3]
ISIS 298697	DM0WH1L	Discovery agent	N.A.	Investigative	[3]
ISIS 298699	DMB28JW	Discovery agent	N.A.	Investigative	[3]
ISIS 298700	DM3DE98	Discovery agent	N.A.	Investigative	[3]
ISIS 298701	DMVIXND	Discovery agent	N.A.	Investigative	[3]
ISIS 298702	DM4L7NE	Discovery agent	N.A.	Investigative	[3]
ISIS 298711	DMCDWSG	Discovery agent	N.A.	Investigative	[3]
ISIS 298712	DMGJ4AO	Discovery agent	N.A.	Investigative	[3]
ISIS 298743	DMD3NSQ	Discovery agent	N.A.	Investigative	[3]
ISIS 298744	DM8VMQ4	Discovery agent	N.A.	Investigative	[3]
ISIS 298745	DM9YMPI	Discovery agent	N.A.	Investigative	[3]
ISIS 298746	DMHOJ0Z	Discovery agent	N.A.	Investigative	[3]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6305-10.
• [3] US patent application no. 7,217,572, Modulation of HIF1.alpha. and HIF2.alpha. expression.