Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTSYFMA)

• DTT Name: Interferon alpha/beta receptor 1 (IFNAR1) DTT Info
• Gene Name: IFNAR1

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EMZ701	DMDEL3F	Hepatitis B virus infection	1E51.0	Phase 2	[1]
MEDI-546	DMPKWR3	Ovarian cancer	2C73	Phase 2	[2]
R-IFN-1a	DMO9QB8	Hepatitis C virus infection	1E51.1	Phase 2	[3]
Belerofon	DM9R0VA	Hepatitis C virus infection	1E51.1	Phase 1	[4]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Omega interferon	DMX6GFR	Hepatitis C virus infection	1E51.1	Discontinued in Phase 2	[5]
BLX-883	DMR7WYX	Hepatitis C virus infection	1E51.1	Discontinued in Phase 1	[6]

References

• [1] Patent EP2766021 A1.
• [2] Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-alpha receptor 1 antibody. MAbs. 2015;7(2):428-39.
• [3] Further study on the specificity and incidence of neutralizing antibodies to interferon (IFN) in relapsing remitting multiple sclerosis patients treated with IFN beta-1a or IFN beta-1b. J Neurol Sci.1999 Oct 15;168(2):131-6.
• [4] WO patent application no. 2009,0153,36, Controlled release interferon drug products and treatment of hcv infection using same.
• [5] Human interferon omega--a review. Mult Scler. 1995;1 Suppl 1:S44-7.
• [6] Patent CN103536906 A.