Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTSZ8T1)

DTT Name	Histone-lysine N-methyltransferase (HLNM) DTT Info
Gene Name	DOT1L

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EPZ-5676	DMN2FS3	Acute myeloid leukaemia	2A60	Phase 1/2	[1]
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3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
bromo-deaza-SAH	DMX2U7G	Discovery agent	N.A.	Investigative	[2]
EPZ-004777	DMLN4V5	leukaemia	2A60-2B33	Investigative	[3]
SGC0946	DMP35VS	Discovery agent	N.A.	Investigative	[4]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood. 2013 August 8; 122(6): 1017-1025.
2	Bromo-deaza-SAH: a potent and selective DOT1L inhibitor. Bioorg Med Chem. 2013 Apr 1;21(7):1787-94.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7377).
4	Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun. 2012;3:1288.