Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTT1JVS)

• DTT Name: Cytosolic phospholipase A2 (GIVA cPLA2) DTT Info
• Gene Name: PLA2G4A

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZPL521	DMPZE2G	Atopic dermatitis	EA80	Phase 1/2	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EFIPLADIB	DMJ0A5U	Asthma	CA23	Terminated	[2]

44 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-Ethyl 6-(2-oxohexadecanamido)decanoate	DMFSXTJ	Discovery agent	N.A.	Investigative	[3]
(S)-Methyl 4-(2-oxohexadecanamido)octanoate	DM8H0ND	Discovery agent	N.A.	Investigative	[3]
(S)-tert-Butyl 4-(2-oxohexadecanamido)pentanoate	DMLG8Q2	Discovery agent	N.A.	Investigative	[3]
(Z)-1,1,1,2,2,3,3-heptafluorohenicos-12-en-4-one	DMSVBZO	Discovery agent	N.A.	Investigative	[4]
1,1,1,2,2,3,3,5-octafluoro-8-phenyloctan-4-one	DMWHN2J	Discovery agent	N.A.	Investigative	[4]
1,1,1,2,2,3,3-heptafluoro-8-phenyloctan-4-ol	DM45NF1	Discovery agent	N.A.	Investigative	[4]
1,1,1,2,2,4-hexafluoro-7-phenylheptan-3-one	DMN68K4	Discovery agent	N.A.	Investigative	[4]
1,1,1,2,2-Pentafluoro-8-phenyl-octan-3-one	DM7U8LD	Discovery agent	N.A.	Investigative	[5]
1,1,1,2,2-Pentafluoro-9-phenyl-nonan-3-one	DMSEHNV	Discovery agent	N.A.	Investigative	[5]
1,1,1,3-Tetrafluoro-6-phenylhexan-2-one	DMLDH4Z	Discovery agent	N.A.	Investigative	[4]
1,1,1,3-Tetrafluoro-7-phenylheptan-2-one	DMV0CXN	Discovery agent	N.A.	Investigative	[4]
1,1,1,3-Tetrafluoro-heptadecan-2-one	DMD36WS	Discovery agent	N.A.	Investigative	[5]
1,1,1-Trifluoro-4-(4-hexyloxy-phenyl)-butan-2-one	DMODCAM	Discovery agent	N.A.	Investigative	[5]
1,1,1-Trifluoro-5-(4-octylphenoxy)pentan-2-one	DMI2XWY	Discovery agent	N.A.	Investigative	[4]
1,1,1-Trifluoro-6-(4-hexyloxy-phenyl)-hexan-2-one	DMCAQ5T	Discovery agent	N.A.	Investigative	[5]
1,1,1-Trifluoro-6-(naphthalen-2-yl)hexan-2-one	DMZ2VE3	Discovery agent	N.A.	Investigative	[4]
1,1,1-Trifluoro-7-phenylheptan-2-one	DMLHVWP	Discovery agent	N.A.	Investigative	[5]
1,1,1-Trifluoro-8-phenyl-octan-2-one	DMYENI7	Discovery agent	N.A.	Investigative	[5]
1,1,1-trifluoroheptadecan-2-one	DMB5U3P	Discovery agent	N.A.	Investigative	[5]
1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one	DM3JHVL	Discovery agent	N.A.	Investigative	[6]
4-(2-oxohexadecanamido)butanoic acid	DMBMJC5	Discovery agent	N.A.	Investigative	[7]
4-(4-Decyloxy-phenyl)-1,1,1-trifluoro-butan-2-one	DMCDKHJ	Discovery agent	N.A.	Investigative	[5]
6-(4-Decyloxy-phenyl)-1,1,1-trifluoro-hexan-2-one	DMYQB5R	Discovery agent	N.A.	Investigative	[5]
Allyl 4-(2-oxohexadecanamido)butanoate	DM8R5AS	Discovery agent	N.A.	Investigative	[3]
AR-C70484XX	DMU3A57	Discovery agent	N.A.	Investigative	[6]
ARACHIDONYL TRIFLUOROMETHYLKETONE	DMHL48F	Discovery agent	N.A.	Investigative	[8]
AX-006	DMDWCY7	Discovery agent	N.A.	Investigative	[9]
AX-048	DMIDXSN	Discovery agent	N.A.	Investigative	[9]
ECOPLADIB	DMWKS29	Discovery agent	N.A.	Investigative	[2]
Ethyl 2-(2-oxohexadecanamido)acetate	DM762HQ	Discovery agent	N.A.	Investigative	[3]
Ethyl 4-(2-oxohexadecanamido)benzoate	DMB12M7	Discovery agent	N.A.	Investigative	[3]
Methyl 2-(2-oxo-8-phenyloctanamido)acetate	DMBKU9M	Discovery agent	N.A.	Investigative	[3]
Methyl 2-(2-oxohexadecanamido)acetate	DMVYGBU	Discovery agent	N.A.	Investigative	[3]
Methyl arachidonyl fluorophosphonate	DMAXEH3	Discovery agent	N.A.	Investigative	[8]
N-(4-Ethoxybutyl)-2-oxohexadecanamide	DM012TN	Discovery agent	N.A.	Investigative	[3]
Tert-Butyl 2-(2-oxohexadecanamido)acetate	DMWQFY6	Discovery agent	N.A.	Investigative	[3]
Tert-Butyl 3-(2-oxo-8-phenyloctanamido)propanoate	DMNU9WV	Discovery agent	N.A.	Investigative	[3]
Tert-Butyl 3-(2-oxohexadecanamido)propanoate	DMYQXPB	Discovery agent	N.A.	Investigative	[3]
Tert-Butyl 5-(2-oxohexadecanamido)pentanoate	DM1ALTR	Discovery agent	N.A.	Investigative	[3]
WAY-196025	DMNH0CM	Discovery agent	N.A.	Investigative	[2]
[3,4''']biflavone	DMHU4NS	Discovery agent	N.A.	Investigative	[10]
[4',4''']-biflavone	DM7JSQL	Discovery agent	N.A.	Investigative	[10]
[6,3''']biflavone	DMA9PW7	Discovery agent	N.A.	Investigative	[10]
[6,4''']biflavone	DMVOX4L	Discovery agent	N.A.	Investigative	[10]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors. J Med Chem. 2009 Feb 26;52(4):1156-71.
• [3] Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69.
• [4] Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10.
• [5] Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37.
• [6] 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52.
• [7] Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha. J Med Chem. 2007 Mar 22;50(6):1380-400.
• [8] 85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells. Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282(4):G586-97.
• [9] 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. Bioorg Med Chem. 2009 Jul 1;17(13):4833-43.
• [10] Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Bioorg Med Chem. 2007 Nov 15;15(22):7138-43.