General Information of DTT (ID: TTT1R2L)

DTT Name Integrin alpha-V (ITGAV) DTT Info
Gene Name ITGAV

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
2 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Abituzumab DMTCXSG Colorectal cancer 2B91.Z Phase 2 [1]
IMGN-388 DMSYB83 Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
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1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
SB-223245 DM3JQCF N. A. N. A. Terminated [3]
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56 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ac-Asp-Arg-Leu-Asp-Ser-OH DMYHADT Discovery agent N.A. Investigative [4]
AcDRGDS DM9MDBO Discovery agent N.A. Investigative [5]
C(-GRGDfL-) DMTMJAI Discovery agent N.A. Investigative [6]
C(Arg-Gly-Asp-D-Phe-Val) DMHNZGP Discovery agent N.A. Investigative [7]
C(RGDfF) DMMBESU Discovery agent N.A. Investigative [8]
C(RGDfMeF) DM8DU42 Discovery agent N.A. Investigative [8]
C-[-Arg-Gly-Asp-Acpca30-] DML0U8B Discovery agent N.A. Investigative [9]
C-[-Arg-Gly-Asp-Acpca31-] DMKENFU Discovery agent N.A. Investigative [9]
C-[-Arg-Gly-Asp-Acpca32-] DMVM7B2 Discovery agent N.A. Investigative [9]
C-[-Arg-Gly-Asp-Acpca33-] DMIBGWO Discovery agent N.A. Investigative [9]
Cyclo(RGDfV) (control) DM3QVOB Discovery agent N.A. Investigative [10]
Cyclo-[-Arg-Gly-Asp-Amp21-] DMVXPUB Discovery agent N.A. Investigative [11]
Cyclo-[-Arg-Gly-Asp-Amp22-] DMBELJK Discovery agent N.A. Investigative [11]
Cyclo-[-Arg-Gly-Asp-Amp23-] DMT29VJ Discovery agent N.A. Investigative [11]
Cyclo-[-Arg-Gly-Asp-Amp24-] DM35ZLK Discovery agent N.A. Investigative [11]
Cyclo-[-Arg-Gly-Asp-Amp25-] DMEIXUQ Discovery agent N.A. Investigative [11]
Cyclo-[-Arg-Gly-Asp-Amp26-] DME5HRW Discovery agent N.A. Investigative [11]
Cyclo-[-Arg-Gly-Asp-Amp27-] DMBNJZ0 Discovery agent N.A. Investigative [11]
Cyclo-[-Arg-Gly-Asp-Amp28-] DMJMHAV Discovery agent N.A. Investigative [11]
CYCLORGDFV DMGZ0KM N. A. N. A. Investigative [12]
Cyclo[RGDfK(cypate)] DMWYFLD Discovery agent N.A. Investigative [10]
Cypate-[(RGD)2-NH2]1 DMBTU7G Discovery agent N.A. Investigative [10]
Cypate-[(RGD)2-NH2]2 DMJNW9P Discovery agent N.A. Investigative [10]
Cypate-[(RGD)3-NH2]1 DMWINK5 Discovery agent N.A. Investigative [10]
Cypate-[(RGD)3-NH2]2 DM1SAIX Discovery agent N.A. Investigative [10]
Cypate-[(RGD)4-NH2]1 DM3GLMP Discovery agent N.A. Investigative [10]
Cypate-[(RGD)4-NH2]2 DMR74OM Discovery agent N.A. Investigative [10]
C[-Arg-Gly-Asp-Acpca19-] DMPOIDK Discovery agent N.A. Investigative [9]
C[-Arg-Gly-Asp-Acpca20-] DMJVW1N Discovery agent N.A. Investigative [9]
C[-Arg-Gly-Asp-Acpca21-] DMXCUDV Discovery agent N.A. Investigative [9]
C[-Arg-Gly-Asp-Acpca22-] DM6DV90 Discovery agent N.A. Investigative [9]
C[-Arg-Gly-Asp-Acpca34-] DMKHSAV Discovery agent N.A. Investigative [9]
C[-Arg-Gly-Asp-Acpca35-] DMQOY3J Discovery agent N.A. Investigative [9]
C[-Arg-Gly-Asp-Acpca36-] DM7LCPW Discovery agent N.A. Investigative [9]
C[RGD-(R)-alpha-TfmfV] DMF091Y Discovery agent N.A. Investigative [8]
C[RGD-(S)-alpha-TfmfV] DMC9G2Y Discovery agent N.A. Investigative [8]
C[RGDf-(3R)-Carboxymorpholine] DM1DMR2 Discovery agent N.A. Investigative [13]
C[RGDf-(3S)-Carboxymorpholine] DM0ULZM Discovery agent N.A. Investigative [13]
C[RGDf-(R)-alpha-TfmF] DMXA0JB Discovery agent N.A. Investigative [8]
C[RGDf-(R)-alpha-TfmV] DM8FGMA Discovery agent N.A. Investigative [8]
C[RGDf-(R)-N-Me-alpha-TfmF] DM4ZWOD Discovery agent N.A. Investigative [8]
C[RGDf-(S)-alpha-TfmF] DMCXJOL Discovery agent N.A. Investigative [8]
C[RGDf-(S)-alpha-TfmV] DMLRYXK Discovery agent N.A. Investigative [8]
C[RGDf-(S)-N-Me-alpha-TfmF] DMNS3HC Discovery agent N.A. Investigative [8]
C[RGDf-(S,R)-alpha-Dfm-F] DMAILK8 Discovery agent N.A. Investigative [8]
E[c(RGDyK)]2 DM76UJY Discovery agent N.A. Investigative [14]
E[c(RGDyK)]2-PTX conjugate DMS1LZI Discovery agent N.A. Investigative [14]
G(D-Pen)-G-H-R-G-D-L-R-C-A DMUC0F5 Discovery agent N.A. Investigative [15]
Gly-Arg-Gly-Asp-Ser DMACT8D Discovery agent N.A. Investigative [16]
Gly-Arg-Gly-Asp-Ser-Pro-Lys DMGOIME Discovery agent N.A. Investigative [17]
ISONIPECOTAMIDE DM5DKUY Discovery agent N.A. Investigative [18]
N-(3,5-dichlorophenyl)imidodicarbonimidic diamide DMQ0LF2 Discovery agent N.A. Investigative [19]
NAVPNLRGDLQVLAQKVART DM3RP25 Discovery agent N.A. Investigative [20]
RGDechi DMX4JN6 Discovery agent N.A. Investigative [7]
SB-265123 DM8UKH7 Discovery agent N.A. Investigative [21]
ST-1646 DMR1G40 Discovery agent N.A. Investigative [11]
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⏷ Show the Full List of 56 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial. Ann Oncol. 2015 Jan;26(1):132-40.
2 Anti-alphav integrin monoclonal antibody intetumumab enhances the efficacy of radiation therapy and reduces metastasis of human cancer xenografts in nude rats. Cancer Res. 2010 Oct 1;70(19):7591-9.
3 Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a resten... Bioorg Med Chem Lett. 1998 Nov 17;8(22):3171-6.
4 Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one sc... Bioorg Med Chem. 2007 Dec 1;15(23):7380-90.
5 Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2329-33.
6 Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81.
7 Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior. J Med Chem. 2006 Jun 1;49(11):3416-20.
8 Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17.
9 Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87.
10 Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75.
11 Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82.
12 Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetr... J Med Chem. 2010 Jan 14;53(1):106-18.
13 Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity. Bioorg Med Chem. 2009 Feb 15;17(4):1542-9.
14 Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery. J Med Chem. 2005 Feb 24;48(4):1098-106.
15 Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin alpha IIb beta 3 antagonists. J Med Chem. 1994 Jan 7;37(1):1-8.
16 alphavbeta3 Integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers. J Med Chem. 2009 Nov 26;52(22):7029-43.
17 N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem. 1999 Aug 12;42(16):3033-40.
18 Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5227-32.
19 Emerging targets in osteoporosis disease modification. J Med Chem. 2010 Jun 10;53(11):4332-53.
20 Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands. J Biol Chem. 2007 Mar 30;282(13):9657-65.
21 1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41.