Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTT3ZC9)

• DTT Name: Human immunodeficiency virus Tat protein (HIV tat) DTT Info
• Gene Name: HIV tat

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[1]

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALX-40-4C	DMV934L	Human immunodeficiency virus infection	1C62	Phase 2	[2]
Ro-24-7429	DMA2UYE	Human immunodeficiency virus infection	1C62	Phase 2	[3]
Anti-HIV ribozyme therapy	DMQZJ3B	Human immunodeficiency virus infection	1C62	Phase 1/2	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EM-2487	DMG9R8E	Human immunodeficiency virus infection	1C62	Terminated	[5]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CGP 40336A	DMEA5BZ	Discovery agent	N.A.	Investigative	[6]
Durhamycin A	DM29PTO	Discovery agent	N.A.	Investigative	[7]

References

• [1] Docking studies reveal a selective binding of D-penicillamine to the transactivator protein of human immunodeficiency virus type 1. FEBS Lett. 2002 Apr 10;516(1-3):43-6.
• [2] Anti-human immunodeficiency virus type 1 activity of an oligocationic compound mediated via gp120 V3 interactions. J Virol. 1996 May;70(5):2825-31.
• [3] A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. The AIDS Clinical Trials Group 213 Team. J Infect Dis. 1995 Nov;172(5):1246-52.
• [4] Clinical gene therapy research utilizing ribozymes: application to the treatment of HIV/AIDS. Methods Mol Biol. 2004;252:581-98.
• [5] EM2487, a novel anti-HIV-1 antibiotic, produced by Streptomyces sp. Mer-2487: taxonomy, fermentation, biological properties, isolation and structure elucidation. J Antibiot (Tokyo). 1999 Nov;52(11):971-82.
• [6] RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86.
• [7] Durhamycin A, a potent inhibitor of HIV Tat transactivation. J Nat Prod. 2002 Aug;65(8):1091-5.