Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTTN5QW)

• DTT Name: Serine/threonine-protein kinase pim-1 (PIM1) DTT Info
• Gene Name: PIM1

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SEL-24	DMH064K	Acute myeloid leukaemia	2A60	Phase 1/2	[1]
CXR-1002	DM4GJ50	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

1 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzothiazine derivative 1	DMMVHY4	N. A.	N. A.	Patented	[3]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
leucettine L41	DMBYND6	Discovery agent	N.A.	Investigative	[4]
NCGC00167772-01	DMY8RT9	Discovery agent	N.A.	Investigative	[1]
PMID21982499C14k	DM0VOXN	Discovery agent	N.A.	Investigative	[5]
PMID22136433C20	DMI8217	Discovery agent	N.A.	Investigative	[6]
SMI-4a	DMBLWMS	Non-small-cell lung cancer	2C25	Investigative	[7]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158).
• [2] 123 Antitumor activity of CXR1002, a novel anti-cancer clinical phase compound that induces ER stress and inhibits PIM kinases: Human tumor xenograft efficacy and in vitro mode of action. EJC Supplements, 2010; 8(7):45-46.
• [3] Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.
• [4] Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86.
• [5] 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92.
• [6] 7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13.
• [7] Pim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway. Onco Targets Ther. 2019 Apr 23;12:3043-3050.