Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTTO43N)

• DTT Name: Endothelial plasminogen activator inhibitor (SERPINE1) DTT Info
• Gene Name: SERPINE1

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
THR-18	DMBO021	Asthma	CA23	Phase 2	[1]
DIAPLASININ	DM6OJI1	Thrombosis	DB61-GB90	Phase 1	[2]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
XR-5118	DMIK72F	Solid tumour/cancer	2A00-2F9Z	Terminated	[3]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AR-HO29953XX	DM2PRHX	Discovery agent	N.A.	Investigative	[4]
SIDEROXYLONAL A	DMEIBTY	Discovery agent	N.A.	Investigative	[5]
SIDEROXYLONAL B	DMDP7Y5	Discovery agent	N.A.	Investigative	[5]
Sideroxylonal C	DMSGNM1	Discovery agent	N.A.	Investigative	[5]

References

• [1] THR-18, a 18-mer peptide derived from PAI-1, is neuroprotective and improves thrombolysis by tPA in rat stroke models. Neurol Res. 2011 Nov;33(9):983-90.
• [2] Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. J Thromb Haemost. 2010 Jun;8(6):1333-9.
• [3] Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem. 2004 Jul 1;47(14):3491-4.
• [4] Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3514-8.
• [5] Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens. J Nat Prod. 1999 Feb;62(2):324-6.