Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTU1E82)

• DTT Name: Apoptosis regulator Bcl-xL (BCL-xL) DTT Info
• Gene Name: BCL2L1

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABT-263	DMNE56X	Myelofibrosis	2A20.2	Phase 3	[1]
Obatoclax	DMPF9ZM	Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
APG-1252	DM8O3R9	Small-cell lung cancer	2C25.Y	Phase 1/2	[3]
AZD0466	DMWLZI6	Hematologic tumour	2B33.Y	Phase 1/2	[4]

7 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indole-based analog 2	DM0NEVC	N. A.	N. A.	Patented	[5]
Indole-based analog 3	DMTEYQJ	N. A.	N. A.	Patented	[5]
PMID27744724-Compound-10	DMFKS2P	N. A.	N. A.	Patented	[5]
PMID27744724-Compound-18	DM73S2C	N. A.	N. A.	Patented	[5]
PMID27744724-Compound-21	DM18UA5	N. A.	N. A.	Patented	[5]
PMID27744724-Compound-26	DM8GOH3	N. A.	N. A.	Patented	[5]
PMID27744724-Compound-27	DMV6MLC	N. A.	N. A.	Patented	[5]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID	DMQ1D9A	Discovery agent	N.A.	Investigative	[6]
E-003	DMA9CZV	Solid tumour/cancer	2A00-2F9Z	Investigative	[7]
EAPB0203	DMB7685	T-cell leukaemia	2A90	Investigative	[8]
WEHI-0103122	DMK0OVE	Solid tumour/cancer	2A00-2F9Z	Investigative	[7]

References

• [1] Clinical pipeline report, company report or official report of Roche (2009).
• [2] Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.
• [3] Bcl-2/Bcl-xl inhibitor APG-1252-M1 is a promising therapeutic strategy for gastric carcinoma. Cancer Med. 2020 Jun;9(12):4197-4206.
• [4] Design and optimisation of dendrimer-conjugated Bcl-2/x L inhibitor, AZD0466, with improved therapeutic index for cancer therapy. Commun Biol. 2021 Jan 25;4(1):112.
• [5] Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178.
• [6] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2845).
• [8] EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I-associated adult T-cell leukemia/lymphoma. Blood. 2008 Apr 1;111(7):3770-7.