Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTU9LGY)

DTT Name	Apolipoprotein A messenger RNA (LPA mRNA) DTT Info
Gene Name	LPA

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

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5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pelacarsen	DMY757D	Cardiovascular disease	BA00-BE2Z	Phase 3	[1]
AMG 890	DM3H0IX	Cardiac fibrosis	DB98.8	Phase 2	[2]
ISIS-APO(a)	DMQ3C05	Coronary artery disease	BA80	Phase 2	[3]
LY3819469	DMUDNNF	Elevated Lipoprotein(a)	5C80.1	Phase 2	[4]
SLN360	DMVVU4V	Hyperlipidemia	5C80.Z	Phase 2	[5]
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Molecule Interaction Atlas

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References

1	Lipoprotein(a) and its Significance in Cardiovascular Disease: A Review. JAMA Cardiol. 2022 Jul 1;7(7):760-769.
2	Clinical pipeline report, company report or official report of Amgen.
3	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
4	ClinicalTrials.gov (NCT05565742) A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of LY3819469 in Adults With Elevated Lipoprotein(a). U.S.National Institutes of Health.
5	Recent lipoprotein(a) trials. Curr Opin Lipidol. 2022 Dec 1;33(6):301-308.