Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTUS45N)

• DTT Name: Leukocyte common antigen (PTPRC) DTT Info
• Gene Name: PTPRC

Molecule-Related Drug & Molecule List

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
131I-labelled aCD45	DM3YEV0	Acute myeloid leukaemia	2A60	Phase 3	[1]
Iomab-B	DMZA47Y	Acute myeloid leukaemia	2A60	Phase 3	[2]
[131I]-BC8	DMV86DY	leukaemia	2A60-2B33	Phase 2	[3]
Anti-CD45 mabs	DMZ2D0G	Lymphoma	2A80-2A86	Phase 1	[4]
Iomab-ACT	DMY0QL7	B-cell acute lymphoblastic leukaemia	2B33.3	Phase 1	[5]
LM-CD45	DMR7LKC	Transplant rejection	NE84	Phase 1	[6]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
OX-30	DMVPG1N	Pain	MG30-MG3Z	Terminated	[7]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Asp-BrPmp-Leu	DMJEZ62	Discovery agent	N.A.	Investigative	[8]

References

• [1] 131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission. Blood. 2006 Mar 1;107(5):2184-91.
• [2] Clinical pipeline report, company report or official report of Actinium Pharmaceuticals.
• [3] Development of a marrow transplant regimen for acute leukemia using targeted hematopoietic irradiation delivered by 131I-labeled anti-CD45 antibody, combined with cyclophosphamide and total body irradiation. Blood. 1995 Feb 15;85(4):1122-31.
• [4] CD45 monoclonal antibody-mediated cytolysis of human NK and T lymphoma cells. Haematologica. 2006 Jul;91(7):886-94.
• [5] Clinical pipeline report, company report or official report of Actinium Pharmaceuticals.
• [6] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002932)
• [7] CD45 / PTPRC Antibody, Biotin conjugate (OX-30).
• [8] A protected l-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphatase inhibitors. Bioorg Med Chem. 2010 Dec 15;18(24):8679-86.