General Information of DTT (ID: TTVC37M)

DTT Name Folate receptor alpha (FOLR1) DTT Info
Gene Name FOLR1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
2 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mirvetuximab soravtansine DM5S4LX Ovarian cancer 2C73 Approved [1]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [2]
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10 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
EC20 DMLA1ER Ovarian cancer 2C73 Phase 3 [3]
Farletuzumab DMFLWX1 Non-small-cell lung cancer 2C25.Y Phase 3 [4]
MK-8109 DM84LO5 Ovarian cancer 2C73 Phase 3 [5]
EC-145 DM0KVJC Solid tumour/cancer 2A00-2F9Z Phase 2 [6]
FolateImmune DMB9ADM Renal cell carcinoma 2C90 Phase 2 [7]
BMS-753493 DMDQO0S Solid tumour/cancer 2A00-2F9Z Phase 1/2 [8]
Talotrexin DM1AB4L Solid tumour/cancer 2A00-2F9Z Phase 1/2 [9]
EC0489 DM8RD4T Solid tumour/cancer 2A00-2F9Z Phase 1 [10]
IMGN-853 DMR8OG2 Solid tumour/cancer 2A00-2F9Z Phase 1 [11]
STRO-002 DMC5HXI Ovarian cancer 2C73 Phase 1 [12]
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⏷ Show the Full List of 10 Clinical Trial Drug(s)
Molecule Interaction Atlas

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 EP patent application no. 2822386, Folate receptor alpha binding ligands.
4 Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer.Gynecol Oncol.2013 Jun;129(3):452-8.
5 A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer. Drug Des Devel Ther. 2015; 9: 4989-4996.
6 Significance of Folate Receptor alpha and Thymidylate Synthase Protein Expression in Patients with Non-Small Cell Lung Cancer treated with Pemetrexed. J Thorac Oncol. 2013 January; 8(1): 19-30.
7 Responsiveness of the Effective Consumer Scale (EC-17). J Rheumatol. 2009 Sep;36(9):2087-91.
8 A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):321-31.
9 Cancer chemotherapy: targeting folic acid synthesis. Cancer Manag Res. 2010; 2: 293-301.
10 National Cancer Institute Drug Dictionary (drug id 638649).
11 Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. Bioconjug Chem. 2010 Jan;21(1):84-92.
12 Clinical pipeline report, company report or official report of Sutro Biopharma.