Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTW2R9X)

• DTT Name: GTPase NRas (NRAS) DTT Info
• Gene Name: NRAS

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GI-4000	DMTY4PG	Colorectal cancer	2B91.Z	Phase 2	[1]
Mutant ras vaccine	DMM6KZR	Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
Reovirus	DMQ73AY	Head and neck cancer	2D42	Phase 2	[3]
Salirasib	DMRSU4X	Lung cancer	2C25.0	Phase 2	[4]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Perillyl alcohol	DMFWC3O	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[5]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
APC-300	DMNIEHV	Prostate cancer	2C82.0	Investigative	[5]
KA-10X	DM4GSHY	Solid tumour/cancer	2A00-2F9Z	Investigative	[5]

References

• [1] Phase II study of the GI-4000 KRAS vaccine after curative therapy in patients with stage I-III lung adenocarcinoma harboring a KRAS G12C, G12D, or G12V mutation. Clin Lung Cancer. 2014 Nov;15(6):405-10.
• [2] The immunological and clinical effects of mutated ras peptide vaccine in combination with IL-2, GM-CSF, or both in patients with solid tumors. J Transl Med. 2014 Feb 24;12:55.
• [3] Reovirus (Reolysin) as a potential therapy for malignant peripheral nerve sheath tumors.
• [4] The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer. Methods Enzymol. 2008;439:467-89.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2823).