Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTWQM3J)

• DTT Name: Kynureninase (KYNU) DTT Info
• Gene Name: KYNU

Molecule-Related Drug & Molecule List

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-Amino-4-[3-hydroxyphenyl]-4-hydroxybutanoic acid	DM1R3VC	Breast cancer	2C60-2C65	Preclinical	[1]
S-(2-Aminophenyl)-L-cysteine S,S-dioxide	DM9Y05C	Bacterial infection	1A00-1C4Z	Preclinical	[2]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3,6,9,12,15-Pentaoxaheptadecane	DMY8IOP	Discovery agent	N.A.	Investigative	[3]
3-hydroxydesaminokynurenine	DM5T6AM	Discovery agent	N.A.	Investigative	[4]
3-Hydroxyhippuric acid	DM2LBFW	Discovery agent	N.A.	Investigative	[3]
3-methoxydesaminokynurenine	DMHVIK3	Discovery agent	N.A.	Investigative	[4]

References

• [1] 2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase. Bioorg Med Chem Lett. 2002 Feb 11;12(3):361-3.
• [2] Structure, mechanism, and substrate specificity of kynureninase. Biochim Biophys Acta. 2011 Nov;1814(11):1481-8.
• [3] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [4] Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13.