Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTX9IFP)

DTT Name	Ubiquitin thioesterase L1 (UCHL1) DTT Info
Gene Name	UCHL1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LDN-57444	DM1982I	Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]
NSC632839	DMQRZ4T	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LDN-91946	DMTSLGF	Discovery agent	N.A.	Investigative	[3]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells. Int J Mol Sci. 2019 Jul 31;20(15):3733.
2	Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity. Biochem Biophys Res Commun. 2018 Mar 4;497(2):726-733.
3	Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32.