Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTXAJWN)

• DTT Name: IL-1 receptor-associated kinase 1 (IRAK1) DTT Info
• Gene Name: IRAK1

Molecule-Related Drug & Molecule List

4 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indazoletriazolephenyl derivative 1	DMHJDU6	N. A.	N. A.	Patented	[1]
Indazoletriazolephenyl derivative 2	DMWZLK6	N. A.	N. A.	Patented	[1]
Pyrazolopyrimidine and thienopyrimidine amide derivative 1	DM6TB4Z	N. A.	N. A.	Patented	[1]
Pyrazolopyrimidine and thienopyrimidine amide derivative 2	DMFUNH4	N. A.	N. A.	Patented	[1]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IRAK-1/4 inhibitor	DMOQBGP	Discovery agent	N.A.	Investigative	[2]
WO2012007375C1	DMOZATX	Discovery agent	N.A.	Investigative	[3]
WO2012007375C7	DMPI2MA	Discovery agent	N.A.	Investigative	[3]

References

• [1] Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32.
• [2] Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2042).