Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTXDKTO)

• DTT Name: Long transient receptor potential channel 8 (TRPM8) DTT Info
• Gene Name: TRPM8

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[1]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-3263	DM7V2OM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
PF-05105679	DM4QPT0	Pain	MG30-MG3Z	Phase 1	[3]

28 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-(5-fluoro-1H-indol-3-yl)ethanamine	DMHW5FT	Discovery agent	N.A.	Investigative	[4]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine	DMD2QVO	Discovery agent	N.A.	Investigative	[4]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[5]
5-Benzyloxytryptamine	DMOM35G	Discovery agent	N.A.	Investigative	[4]
5-METHOXYTRYPTAMINE	DMARCKD	Discovery agent	N.A.	Investigative	[4]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[6]
AMTB	DM4OCAH	Discovery agent	N.A.	Investigative	[7]
cooling agent 10	DMFH5J9	Discovery agent	N.A.	Investigative	[8]
CPS125	DMG2NI9	Discovery agent	N.A.	Investigative	[9]
eucalyptol	DME5CK3	Discovery agent	N.A.	Investigative	[10]
frescolat MGA	DMEYNGP	Discovery agent	N.A.	Investigative	[8]
frescolat ML	DMIBCZJ	Discovery agent	N.A.	Investigative	[8]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[8]
hydroxycitronellal	DMFHCV9	Discovery agent	N.A.	Investigative	[8]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[11]
isopulegol	DMPYAMU	Discovery agent	N.A.	Investigative	[8]
linalool	DMGZQ5P	Discovery agent	N.A.	Investigative	[8]
M8-B	DM8I0TY	Discovery agent	N.A.	Investigative	[12]
NADA	DM3ORGM	Discovery agent	N.A.	Investigative	[6]
PBMC	DM8K7C4	Discovery agent	N.A.	Investigative	[13]
Perillaldehyde	DMZA0VD	Discovery agent	N.A.	Investigative	[14]
PMD38	DMEYHWN	Discovery agent	N.A.	Investigative	[8]
RQ-00203078	DM83THZ	Neuropathic pain	8E43.0	Investigative	[6]
thio-BCTC	DM76EPH	Discovery agent	N.A.	Investigative	[8]
WS-12	DM48MHL	Discovery agent	N.A.	Investigative	[9]
WS-23	DMT5SXR	Discovery agent	N.A.	Investigative	[8]
WS-3	DM1R8MW	Discovery agent	N.A.	Investigative	[8]
WS-5	DMX1JR0	Discovery agent	N.A.	Investigative	[9]

References

• [1] TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10.
• [2] Best of the 2009 AUA Annual Meeting: Highlights from the 2009 Annual Meeting of the American Urological Association, April 25-30, 2009, Chicago, IL. Rev Urol. 2009 Spring; 11(2): 82-107.
• [3] Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014 Nov;351(2):259-69.
• [4] 5-benzyloxytryptamine as an antagonist of TRPM8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9.
• [5] Effects of antagonists and heat on TRPM8 channel currents in dorsal root ganglion neuron activated by nociceptive cold stress and menthol. Neurochem Res. 2012 Feb;37(2):314-20.
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500).
• [7] AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol. 2008 Sep;295(3):F803-10.
• [8] Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45.
• [9] Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. J Pharm Pharm Sci. 2010;13(2):242-53.
• [10] Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002 Mar 7;416(6876):52-8.
• [11] Evolution of thermal response properties in a cold-activated TRP channel. PLoS One. 2009 May 29;4(5):e5741.
• [12] Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012 Feb 8;32(6):2086-99.
• [13] Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLoS One. 2011;6(9):e25894.
• [14] Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens. Bioorg Med Chem. 2009 Feb 15;17(4):1636-9.