Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTXOZQ1)

DTT Name	ApoC-III messenger RNA (APOC3 mRNA) DTT Info
Gene Name	APOC3

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Volanesorsen	DM1YEPS	Hypertriglyceridemia	5C80.1	Approved	[1]
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3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARO-APOC3	DMABKHH	Familial chylomicronemia syndrome	5C80	Phase 3	[2]
Olezarsen	DMNLSFN	Familial chylomicronemia syndrome	5C80	Phase 3	[3]
ISIS-APOCIII	DMX3FN4	Atherosclerosis	BD40	Phase 1	[4]
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Molecule Interaction Atlas

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References

1	Metabolism and Disposition of Volanesorsen, a 2'- O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species. Drug Metab Dispos. 2019 Oct;47(10):1164-1173.
2	ANGPTL3 and Apolipoprotein C-III as Novel Lipid-Lowering Targets. Curr Atheroscler Rep. 2021 Mar 10;23(5):20.
3	Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk. Eur Heart J. 2022 Apr 6;43(14):1401-1412.
4	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).