Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTXU3EQ)

• DTT Name: Herpesvirus ubiquitin-specific protease (HAUSP) DTT Info
• Gene Name: USP7

Molecule-Related Drug & Molecule List

2 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID26077642-Compound-Vif1	DMS9KCF	N. A.	N. A.	Patented	[1]
PMID26077642-Compound-Vif2	DMYXIS7	N. A.	N. A.	Patented	[1]

5 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ADC-01	DM19R28	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
ADC-03	DM21I35	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
HBX19818	DM6GSI1	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
P22077	DMD8JIC	Inflammation	1A00-CA43.1	Preclinical	[4]
P5091	DMGIR3F	Solid tumour/cancer	2A00-2F9Z	Preclinical	[5]

References

• [1] Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208.
• [2] Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics. Cancers (Basel). 2020 Jun 15;12(6):1579.
• [3] Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8(8):2286-95.
• [4] P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6. Aging (Albany NY). 2020 Jun 9;12(11):10969-10982.
• [5] USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. Biochem Pharmacol. 2017 May 1;131:29-39.