General Information of DTT (ID: TTY6EWA)

DTT Name Neuropeptide Y receptor type 5 (NPY5R) DTT Info
Gene Name NPY5R

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
5 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
CGP71683A DMRYC08 Obesity 5B81 Discontinued in Phase 3 [1]
Velneperit DMROSHN Obesity 5B81 Discontinued in Phase 2 [2]
Axovan-3 DM1JN6A Eating disorder 6B82 Discontinued in Phase 1 [3]
S-234462 DM80P4U Obesity 5B81 Discontinued in Phase 1 [2]
RWJ-49815 DMUGZMO Fungal infection 1F29-1F2F Terminated [3]
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3 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
FR-79620 DMXR287 Diabetic complication 5A2Y Preclinical [4]
GW-594884A DMHUD27 Obesity 5B81 Preclinical [4]
NPY5RA-972 DMXUCSN Obesity 5B81 Preclinical [4]
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13 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
2,4,4-triphenylimidazoline DMS8I1E Discovery agent N.A. Investigative [5]
AR-129330 DMUSYKG Discovery agent N.A. Investigative [6]
Bis(31/31')[[Cys(31), Nva(34)]NPY(27-36)-NH(2)] DMKANOH Discovery agent N.A. Investigative [7]
FMS586 DMQBTL3 Discovery agent N.A. Investigative [8]
FR-226928 DMBY3T5 Discovery agent N.A. Investigative [9]
FR-230481 DMKJQWR Discovery agent N.A. Investigative [9]
FR-233118 DMPD16N Discovery agent N.A. Investigative [9]
FR-73966 DMV0UM2 Discovery agent N.A. Investigative [9]
JCF 109 DMYF7AE Discovery agent N.A. Investigative [10]
L-152,804 DMVGX7Z Discovery agent N.A. Investigative [11]
LU-AA33810 DM34AYV Major depressive disorder 6A70.3 Investigative [12]
S-19528 DM589XM Eating disorder 6B82 Investigative [3]
S-25585 DMBUD1M Eating disorder 6B82 Investigative [3]
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⏷ Show the Full List of 13 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors. Neuropharmacology. 2007 May;52(6):1396-402.
2 Clinical pipeline report, company report or official report of Shionogi (2011).
3 Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36.
4 Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
5 Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1670-4.
6 Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3853-6.
7 Bis(31/31')[[Cys(31), Nva(34)]NPY(27-36)-NH(2)]: a neuropeptide Y (NPY) Y(5) receptor selective agonist with a latent stimulatory effect on food intake in rats. Peptides. 2002 Aug;23(8):1485-90.
8 Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin... J Pharmacol Exp Ther. 2006 May;317(2):562-70.
9 Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 3: 7-methoxy-1-hydroxy-1-substituted tetraline derivatives. Bioorg Med Chem Lett. 2002 Mar 11;12(5):799-802.
10 Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY. Br J Pharmacol. 2003 Aug;139(7):1360-8.
11 L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73.
12 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 308).