Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTYM8DJ)

• DTT Name: Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) DTT Info
• Gene Name: ENTPD1

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IPH5201	DMFEI6T	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
SRF617	DMTK1BV	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
TTX-030	DM8H2AG	Lymphoma	2A80-2A86	Phase 1	[3]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PSB-0963	DMBDVJ1	Discovery agent	N.A.	Investigative	[4]
PSB-6426	DMJ9ML8	Discovery agent	N.A.	Investigative	[5]

References

• [1] ClinicalTrials.gov (NCT04261075) IPH5201 as Monotherapy or in Combination With Durvalumab +/- Oleclumab in Subjects With Advanced Solid Tumors.. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of Surface oncology.
• [3] Clinical pipeline report, company report or official report of AbbVie.
• [4] Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86.
• [5] Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. J Med Chem. 2008 Aug 14;51(15):4518-28.