General Information of DTT (ID: TTYT93M)

DTT Name MAP kinase p38 (MAPK12) DTT Info
Gene Name MAPK12

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
SM-101 DMFX9O6 Idiopathic thrombocytopenic purpura 3B64.10 Approved (orphan drug) [1]
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2 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ARRY-797 DMJ48AB Dilated cardiomyopathy BC43.0 Phase 2 [2]
VX-745 DMJAEG6 Alzheimer disease 8A20 Phase 2 [3]
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2 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
KC706 DMBX6C7 Cardiovascular disease BA00-BE2Z Discontinued in Phase 2 [4]
SB 235699 DMNH8XU Psoriasis vulgaris EA90 Discontinued in Phase 1 [5]
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14 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [6]
AMP-PNP DMTOK1D Discovery agent N.A. Investigative [7]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [8]
CI-1040 DMF3DZX Discovery agent N.A. Investigative [8]
KN-62 DMLZ89P Discovery agent N.A. Investigative [8]
KT-5720 DM9J50F Discovery agent N.A. Investigative [8]
ML-3163 DM3S5UC Discovery agent N.A. Investigative [9]
ML-3375 DMXJY6W Discovery agent N.A. Investigative [10]
ML-3403 DMTQWI8 Discovery agent N.A. Investigative [10]
Phosphonothreonine DMTFHPI Discovery agent N.A. Investigative [11]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [8]
Ro31-8220 DMDJLF0 Discovery agent N.A. Investigative [8]
RWJ-68354 DMNLVRS Discovery agent N.A. Investigative [12]
STAUROSPORINONE DMU2H4K Discovery agent N.A. Investigative [8]
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⏷ Show the Full List of 14 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs. 2008 Sep;13(3):447-63.
2 Array BioPharmas ARRY-797 Meets Primary Endpoint in Clinical Proof of Concept Trial in Osteoarthritis Patients Whose Pain is Poorly Controlled by NSAIDs
3 P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis. J Inflamm (Lond). 2008 Dec 4;5:22.
4 KC706, an Oral p38 MAP Kinase Inhibitor, Increases HDL-C. Circulation. 2007;116:II_126.
5 Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J Med Chem. 2003 Dec 18;46(26):5651-62.
6 Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47.
7 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
8 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
9 From imidazoles to pyrimidines: new inhibitors of cytokine release. J Med Chem. 2002 Jun 20;45(13):2733-40.
10 Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44.
11 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
12 Imidazopyrimidines, potent inhibitors of p38 MAP kinase. Bioorg Med Chem Lett. 2003 Feb 10;13(3):347-50.